Structural Biology and Pharmacology

Structural Biology and Pharmacology

Teachers: Andrea Mattevi, Kurt Faber
Year: 2018/2019
ECTS: 6
SSD: BIO/11

Course content

Requirements
Bachelor-level knowledge of molecular biology, chemistry and math.

Objectives
This course investigates the fundamental concepts and methods for the study of the structures of biological macromolecules with a focus on the implications for drug development and design.

Programme
Methods for the study of the three-dimensional structure of biological macromolecules.
Introduction to biocrystallography.
Diffraction theory.
The phase problem and methods for its solution.
Experimental methods in biocrystallography.
NMR spectroscopy
Multidimensional NMR
Other methods for structural biology (electron microscopy, mass spectrometry)
Structure-based drug design
Examples of the application of the structural biology methods for drug development

Bibliography
Sheehan D. Physical Biochemistry: Principles and Applications, 2nd Edition. Wiley-Blackwell