Teachers: Giovanna Riccardi, Silvia Buroni
Basic knowledge of Genetics and Biochemistry.
The role of bacterial pathogens and viruses in human health.
Host-pathogen interaction. Innate and adaptive immunity. Phagocytosis process. Autophagy in infectious diseases. Antigen processing and presentation. Microbial pathogenesis: adhesion/invasion, Type III Secretion Systems, iron acquisition, evasion of host defences, antigenic variation, endotoxin and esotoxins. Immunotoxins.Patogenicity Islands. Tuberculosis as a model of host-pathogen interaction. Multidrug resistance and efflux pumps. New antibacterial drugs. Quorum sensing and biofilm. Phage therapy. Animal viruses: HIV, HCV, HPV, flu viruses. Ebola virus and Zika virus. Old and new vaccines.
Slides plus articles and reviews.